The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma.
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| Title: | The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma. |
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| Authors: | Hruby L; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Schaal K; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, 02114, MA, USA., Picard D; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany., Dunham C; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Lewandowska O; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany., Reiff T; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany., Larcher M; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France., Pouponnot C; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Rotblat B; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Reifenberger G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany., Remke M; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany., Leprivier G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. gabriel.leprivier@med.uni-duesseldorf.de. |
| Source: | Cell death discovery [Cell Death Discov] 2025 Jul 16; Vol. 11 (1), pp. 330. Date of Electronic Publication: 2025 Jul 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-025-02601-x |
