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The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma.

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Title: The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma.
Authors: Hruby L; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Schaal K; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, 02114, MA, USA., Picard D; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany., Dunham C; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Lewandowska O; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany., Reiff T; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany., Larcher M; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France., Pouponnot C; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Rotblat B; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Reifenberger G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany., Remke M; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany., Leprivier G; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. gabriel.leprivier@med.uni-duesseldorf.de.
Source: Cell death discovery [Cell Death Discov] 2025 Jul 16; Vol. 11 (1), pp. 330. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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  Data: The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Hruby+L%22">Hruby L</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schaal+K%22">Schaal K</searchLink>; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Delaidelli+A%22">Delaidelli A</searchLink>; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, 02114, MA, USA.<br /><searchLink fieldCode="AU" term="%22Picard+D%22">Picard D</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany.<br /><searchLink fieldCode="AU" term="%22Dunham+C%22">Dunham C</searchLink>; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lewandowska+O%22">Lewandowska O</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Reiff+T%22">Reiff T</searchLink>; Institute of Genetics, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Larcher+M%22">Larcher M</searchLink>; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pouponnot+C%22">Pouponnot C</searchLink>; Institut Curie, Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sorensen+PH%22">Sorensen PH</searchLink>; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Rotblat+B%22">Rotblat B</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Reifenberger+G%22">Reifenberger G</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Remke+M%22">Remke M</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology and Hematology, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg/Saar, Germany.<br /><searchLink fieldCode="AU" term="%22Leprivier+G%22">Leprivier G</searchLink>; Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. gabriel.leprivier@med.uni-duesseldorf.de.
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