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Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.

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Bibliographic Details
Title: Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.
Authors: Trivedi MR; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Joshi AM; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Shah J; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Readhead BP; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA., Wilson MA; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Center for Evolution and Medicine, Arizona State University, Tempe, USA.; The Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, USA., Su Y; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA., Wu T; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Wang Q; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. Qi.Wang.10@asu.edu.
Source: Npj aging [NPJ Aging] 2025 Jul 16; Vol. 11 (1), pp. 66. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-6068
DOI:10.1038/s41514-025-00258-5