Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes.

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Title: Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes.
Authors: Singh PJ; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.; US Department of Veterans Affairs, Veterans Affairs Medical Center, Fayetteville, AR, USA., Verma B; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Wells A; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Mendes CC; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Dunn D; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Chen YN; Department of Life Sciences, National Central University, Taoyuan City, Taiwan., Oh J; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Blincowe L; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Wainwright SM; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK., Fischer R; Target Discovery Institute, University of Oxford, Oxford, UK., Fan SJ; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.; Department of Life Sciences, National Central University, Taoyuan City, Taiwan., Harris AL; Department of Oncology, University of Oxford, Oxford, UK., Goberdhan DCI; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Wilson C; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK. clive.wilson@dpag.ox.ac.uk.
Source: The EMBO journal [EMBO J] 2025 Aug; Vol. 44 (16), pp. 4443-4472. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00497-y