Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.

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Bibliographic Details
Title: Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.
Authors: Lu B; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Sun YY; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Zhou JH; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Chen DN; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Guo Y; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Chen YL; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Pan CH; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China., Chen ZY; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., He QJ; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China., Yuan M; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China., Cao J; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. caoji88@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn., Jiang L; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. jiangli49@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn., Yang B; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. yang924@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. yang924@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China. yang924@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3302-3313. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01616-5