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Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.

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Title: Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.
Authors: Lu B; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Sun YY; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Zhou JH; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Chen DN; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Guo Y; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Chen YL; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Pan CH; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China., Chen ZY; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., He QJ; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China., Yuan M; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China., Cao J; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. caoji88@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn., Jiang L; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. jiangli49@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn., Yang B; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. yang924@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. yang924@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China. yang924@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3302-3313. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.
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  Data: <searchLink fieldCode="AU" term="%22Lu+B%22">Lu B</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Sun+YY%22">Sun YY</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zhou+JH%22">Zhou JH</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+DN%22">Chen DN</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+YL%22">Chen YL</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Pan+CH%22">Pan CH</searchLink>; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China.<br /><searchLink fieldCode="AU" term="%22Chen+ZY%22">Chen ZY</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22He+QJ%22">He QJ</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China.; Cancer Center, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Yuan+M%22">Yuan M</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. caoji88@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. caoji88@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. caoji88@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. jiangli49@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, 310058, China. jiangli49@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, 310018, China. yang924@zju.edu.cn.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, 310018, China. yang924@zju.edu.cn.; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, 310000, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China. yang924@zju.edu.cn.
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        Value: 10.1038/s41401-025-01616-5
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              Text: 2025 Dec
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