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BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.

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Bibliographic Details
Title: BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.
Authors: El Bouazzaoui L; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands., Bugter JM; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Küçükköse E; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Verheem A; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Post JB; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Fenderico N; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Borel Rinkes IHM; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Snippert HJG; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Maurice MM; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands., Kranenburg O; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands.
Source: IScience [iScience] 2025 Jun 14; Vol. 28 (7), pp. 112905. Date of Electronic Publication: 2025 Jun 14 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.112905