Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen.
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| Title: | Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V |
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| Authors: | Damsbo A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Bactolife A/S, Copenhagen, Denmark., Burlet NJ; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernández-Quintero ML; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Benard-Valle M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Guadarrama-Martínez A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Vlamynck A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Bisbo I; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Villalobos C; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Tulika T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Alagón A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Boddum K; Sophion Bioscience A/S, Ballerup, Denmark., Morth JP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. erdto@dtu.dk., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk. |
| Source: | Communications chemistry [Commun Chem] 2025 Jul 19; Vol. 8 (1), pp. 209. Date of Electronic Publication: 2025 Jul 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3669 |
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| DOI: | 10.1038/s42004-025-01600-4 |