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Pathology-oriented multiplexing enables integrative disease mapping.

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Title: Pathology-oriented multiplexing enables integrative disease mapping.
Authors: Kuehl M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. malte.kuehl@clin.au.dk.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. malte.kuehl@clin.au.dk.; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk., Okabayashi Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. y_okabayashi@jikei.ac.jp.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. y_okabayashi@jikei.ac.jp.; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. y_okabayashi@jikei.ac.jp., Wong MN; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gernhold L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gut G; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Kaiser N; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwerk M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gräfe SK; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ma FY; Department of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia., Tanevski J; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.; Translational Spatial Profiling Center, Heidelberg University Hospital, Heidelberg, Germany., Schäfer PSL; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany., Mezher S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sarabia Del Castillo J; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Goldbeck-Strieder T; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zolotareva O; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Hartung M; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Delgado Chaves FM; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany., Klinkert L; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gnirck AC; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Euroimmun, Lübeck, Germany., Spehr M; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Fleck D; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Joodaki M; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany., Parra V; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany., Shaigan M; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany., Diebold M; Faculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Prinz M; Faculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Kranz J; Department of Urology and Pediatric Urology, University Hospital RWTH Aachen, Aachen, Germany.; Department of Urology and Kidney Transplantation, Martin-Luther-University, Halle, Germany., Kux JM; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Braun F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kretz O; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wu H; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Grahammer F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Heins S; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zimmermann M; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Haas F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kylies D; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wanner N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Czogalla J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dumoulin B; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zolotarev N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lindenmeyer M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Karlson P; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nyengaard JR; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark., Sebode M; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Weidemann S; Department of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Wiech T; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Groene HJ; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Pharmacology, University of Marburg, Marburg, Germany., Tomas NM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meyer-Schwesinger C; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Experimental Medicine, Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kuppe C; Department of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany., Kramann R; Department of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany., Karras A; Department of Nephrology, Georges Pompidou European Hospital, APHP, Université Paris Cité, Paris, France., Bruneval P; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France., Tharaux PL; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France., Pastene D; V. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Yard B; V. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany., Schaub JA; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA., McCown PJ; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA., Pyle L; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA., Choi YJ; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA., Yokoo T; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Baumbach J; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark., Sáez PJ; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Costa I; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany., Turner JE; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hodgin JB; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Saez-Rodriguez J; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bjornstad P; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA., Kretzler M; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA., Lenoir O; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France., Nikolic-Paterson DJ; Department of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia., Pelkmans L; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Bonn S; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Puelles VG; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. v.puelles@uke.de.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. v.puelles@uke.de.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de.
Source: Nature [Nature] 2025 Aug; Vol. 644 (8076), pp. 516-526. Date of Electronic Publication: 2025 Jul 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 40681898
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Pathology-oriented multiplexing enables integrative disease mapping.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Kuehl+M%22">Kuehl M</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. malte.kuehl@clin.au.dk.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. malte.kuehl@clin.au.dk.; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. malte.kuehl@clin.au.dk.<br /><searchLink fieldCode="AU" term="%22Okabayashi+Y%22">Okabayashi Y</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. y_okabayashi@jikei.ac.jp.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. y_okabayashi@jikei.ac.jp.; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. y_okabayashi@jikei.ac.jp.<br /><searchLink fieldCode="AU" term="%22Wong+MN%22">Wong MN</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gernhold+L%22">Gernhold L</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gut+G%22">Gut G</searchLink>; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kaiser+N%22">Kaiser N</searchLink>; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwerk+M%22">Schwerk M</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gräfe+SK%22">Gräfe SK</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ma+FY%22">Ma FY</searchLink>; Department of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tanevski+J%22">Tanevski J</searchLink>; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.; Translational Spatial Profiling Center, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer+PSL%22">Schäfer PSL</searchLink>; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mezher+S%22">Mezher S</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sarabia+Del+Castillo+J%22">Sarabia Del Castillo J</searchLink>; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goldbeck-Strieder+T%22">Goldbeck-Strieder T</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zolotareva+O%22">Zolotareva O</searchLink>; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Hartung+M%22">Hartung M</searchLink>; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Delgado+Chaves+FM%22">Delgado Chaves FM</searchLink>; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klinkert+L%22">Klinkert L</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gnirck+AC%22">Gnirck AC</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Euroimmun, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Spehr+M%22">Spehr M</searchLink>; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Fleck+D%22">Fleck D</searchLink>; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Joodaki+M%22">Joodaki M</searchLink>; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Parra+V%22">Parra V</searchLink>; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Shaigan+M%22">Shaigan M</searchLink>; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Diebold+M%22">Diebold M</searchLink>; Faculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Prinz+M%22">Prinz M</searchLink>; Faculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kranz+J%22">Kranz J</searchLink>; Department of Urology and Pediatric Urology, University Hospital RWTH Aachen, Aachen, Germany.; Department of Urology and Kidney Transplantation, Martin-Luther-University, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Kux+JM%22">Kux JM</searchLink>; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Braun+F%22">Braun F</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kretz+O%22">Kretz O</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grahammer+F%22">Grahammer F</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heins+S%22">Heins S</searchLink>; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zimmermann+M%22">Zimmermann M</searchLink>; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Haas+F%22">Haas F</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kylies+D%22">Kylies D</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wanner+N%22">Wanner N</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Czogalla+J%22">Czogalla J</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dumoulin+B%22">Dumoulin B</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zolotarev+N%22">Zolotarev N</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lindenmeyer+M%22">Lindenmeyer M</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Karlson+P%22">Karlson P</searchLink>; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nyengaard+JR%22">Nyengaard JR</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Sebode+M%22">Sebode M</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weidemann+S%22">Weidemann S</searchLink>; Department of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wiech+T%22">Wiech T</searchLink>; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Groene+HJ%22">Groene HJ</searchLink>; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Pharmacology, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tomas+NM%22">Tomas NM</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer-Schwesinger+C%22">Meyer-Schwesinger C</searchLink>; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Experimental Medicine, Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuppe+C%22">Kuppe C</searchLink>; Department of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kramann+R%22">Kramann R</searchLink>; Department of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Karras+A%22">Karras A</searchLink>; Department of Nephrology, Georges Pompidou European Hospital, APHP, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bruneval+P%22">Bruneval P</searchLink>; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.<br /><searchLink fieldCode="AU" term="%22Tharaux+PL%22">Tharaux PL</searchLink>; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.<br /><searchLink fieldCode="AU" term="%22Pastene+D%22">Pastene D</searchLink>; V. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Yard+B%22">Yard B</searchLink>; V. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schaub+JA%22">Schaub JA</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22McCown+PJ%22">McCown PJ</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pyle+L%22">Pyle L</searchLink>; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+YJ%22">Choi YJ</searchLink>; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yokoo+T%22">Yokoo T</searchLink>; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Baumbach+J%22">Baumbach J</searchLink>; Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.; Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Sáez+PJ%22">Sáez PJ</searchLink>; Cell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Costa+I%22">Costa I</searchLink>; Institute for Computational Genomics, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Turner+JE%22">Turner JE</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hodgin+JB%22">Hodgin JB</searchLink>; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Saez-Rodriguez+J%22">Saez-Rodriguez J</searchLink>; Institute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+TB%22">Huber TB</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bjornstad+P%22">Bjornstad P</searchLink>; Department of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kretzler+M%22">Kretzler M</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lenoir+O%22">Lenoir O</searchLink>; Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.<br /><searchLink fieldCode="AU" term="%22Nikolic-Paterson+DJ%22">Nikolic-Paterson DJ</searchLink>; Department of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Pelkmans+L%22">Pelkmans L</searchLink>; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonn+S%22">Bonn S</searchLink>; Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Puelles+VG%22">Puelles VG</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. v.puelles@uke.de.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark. v.puelles@uke.de.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. v.puelles@uke.de.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Aug; Vol. 644 (8076), pp. 516-526. <i>Date of Electronic Publication: </i>2025 Jul 18.
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