Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease.

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Title: Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease.
Authors: Li Q; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Koehler S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Koenig A; Cognition-Behavior-Technology group (Cobtek), Université Côte d'Azur, Nice, France.; ki:elements GmbH, Saarbrücken, Germany., Dyrba M; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Mallik E; ki:elements GmbH, Saarbrücken, Germany., Linz N; ki:elements GmbH, Saarbrücken, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany., Spruth E; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Altenstein S; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goetthingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Zerr I; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Department of Neurology, University Medical Center, Georg August University, Goettingen, Germany., Bartels C; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goetthingen, Germany., Maier F; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Duezel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Incesoy EI; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Butryn M; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany., Sodenkamp S; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Munk MH; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Falkenburger B; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Germany., Osterrath A; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Germany., Kilimann I; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Stark M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Heneka MT; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Jessen F; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Petzold GC; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany., Levin F; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany., Teipel S; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Sep; Vol. 107 (1), pp. 154-169. Date of Electronic Publication: 2025 Jul 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1875-8908
DOI:10.1177/13872877251359967