Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS).

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Title: Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS).
Authors: Fung WH; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Wessels MHJ; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. m.wessels@amsterdamumc.nl., Coerver EME; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., de Beukelaar J; Albert Schweitzer Hospital, Neurology, Dordrecht, The Netherlands., Bouvy WH; Diakonessenhuis, Neurology, Utrecht, The Netherlands., Canta LR; Catharina Hospital, Neurology, Eindhoven, The Netherlands., Gerlach OHH; Zuyderland Medical Center, Neurology, Sittard-Geleen, The Netherlands, and School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Hoitsma E; Alrijne Hospital, Neurology, Leiden, The Netherlands., Hoogervorst ELJ; St. Antonius Hospital, Neurology, Utrecht, The Netherlands., de Jong BA; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Kalkers NF; OLVG, Neurology, Amsterdam, The Netherlands., van Kempen ZLE; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Lövenich H; St. Jans Gasthuis, Neurology, Weert, The Netherlands., van Munster CEP; Amphia Hospital, Neurology, Breda, The Netherlands., van Oosten BW; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Smolders J; Erasmus Medical Center, MS center ErasMS, Neurology & Immunology, Rotterdam, The Netherlands., Vennegoor A; Flevoziekenhuis, Neurology, Almere, The Netherlands., Zeinstra EMPE; Isala Hospital, Neurology, Meppel, The Netherlands., Barrantes-Cepas M; MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands., Kooij G; MS Center Amsterdam, Molecular Cell Biology and Immunology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands., Schoonheim MM; MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands., Lissenberg-Witte BI; Department of Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Moraal B; Radiology & Nuclear Medicine, MS Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Barkhof F; Radiology & Nuclear Medicine, MS Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College, London, UK., Uitdehaag BMJ; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Mostert J; Rijnstate Hospital, Neurology, Arnhem, The Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands., Killestein J; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Strijbis EMM; MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Source: Journal of neurology [J Neurol] 2025 Jul 23; Vol. 272 (8), pp. 530. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1459
DOI:10.1007/s00415-025-13231-9