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Discovery of a potent C20-oxime pachysandra alkaloid analogue promising for treatment of hepatocellular carcinoma.

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Title: Discovery of a potent C20-oxime pachysandra alkaloid analogue promising for treatment of hepatocellular carcinoma.
Authors: Zhao CL; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China., Zhang WW; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China., Zhao JF; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China., Ye JH; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China., Wei P; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China., Zou J; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China. Electronic address: zoujuan466@gzy.edu.cn., He K; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 4 Dongqing road, Guiyang 550025, China; Guizhou Provincial Key Laboratory of Miao Medicine, Guiyang 550025, China; Joint International Research Laboratory of Guizhou Ethnomedicine of Ministry of Education, Guiyang 550025, China. Electronic address: hekang@gzy.edu.cn.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118324. Date of Electronic Publication: 2025 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2025.118324