De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
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| Title: | De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells. |
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| Authors: | Johansen KH; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Wolff DS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Scapolo B; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernández-Quintero ML; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Risager Christensen C; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Kjærgaard Munk K; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Morell O; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Viuff MC; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Lacunza I; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Damm Englund AT; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Due M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Gharpure A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rodriguez Pardo C; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Tamhane T; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Qingjie Andersen E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Haldrup Björnsson K; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernandes JS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Voss LF; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Thumtecho S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ormhøj M; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Reker Hadrup S; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. |
| Source: | Science (New York, N.Y.) [Science] 2025 Jul 24; Vol. 389 (6758), pp. 380-385. Date of Electronic Publication: 2025 Jul 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adv0422 |
