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De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.

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Title: De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
Authors: Johansen KH; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Wolff DS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Scapolo B; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernández-Quintero ML; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Risager Christensen C; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Kjærgaard Munk K; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Morell O; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Viuff MC; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Lacunza I; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Damm Englund AT; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Due M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Gharpure A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rodriguez Pardo C; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Tamhane T; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Qingjie Andersen E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Haldrup Björnsson K; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernandes JS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Voss LF; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Thumtecho S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ormhøj M; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Reker Hadrup S; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Source: Science (New York, N.Y.) [Science] 2025 Jul 24; Vol. 389 (6758), pp. 380-385. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Johansen+KH%22">Johansen KH</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Wolff+DS%22">Wolff DS</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Scapolo+B%22">Scapolo B</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Fernández-Quintero+ML%22">Fernández-Quintero ML</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Risager+Christensen+C%22">Risager Christensen C</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Loeffler+JR%22">Loeffler JR</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rivera-de-Torre+E%22">Rivera-de-Torre E</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Overath+MD%22">Overath MD</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Kjærgaard+Munk+K%22">Kjærgaard Munk K</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Morell+O%22">Morell O</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Viuff+MC%22">Viuff MC</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Lacunza+I%22">Lacunza I</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Damm+Englund+AT%22">Damm Englund AT</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Due+M%22">Due M</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Gharpure+A%22">Gharpure A</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Pardo+C%22">Rodriguez Pardo C</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Tamhane+T%22">Tamhane T</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Qingjie+Andersen+E%22">Qingjie Andersen E</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Haldrup+Björnsson+K%22">Haldrup Björnsson K</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Fernandes+JS%22">Fernandes JS</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Voss+LF%22">Voss LF</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Thumtecho+S%22">Thumtecho S</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ormhøj+M%22">Ormhøj M</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Reker+Hadrup+S%22">Reker Hadrup S</searchLink>; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Jenkins+TP%22">Jenkins TP</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2025 Jul 24; Vol. 389 (6758), pp. 380-385. <i>Date of Electronic Publication: </i>2025 Jul 24.
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