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The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.

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Bibliographic Details
Title: The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.
Authors: Issa NT; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida., Shen T; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Vizurraga A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Pronin A; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Henry T; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Wang Q; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Kwarcinski FE; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Schürer S; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Badiavas E; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida., Tall GG; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: gregtall@umich.edu., Slepak VZ; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: vslepak@med.miami.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2025 Aug; Vol. 107 (8), pp. 100059. Date of Electronic Publication: 2025 Jul 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-0111
DOI:10.1016/j.molpha.2025.100059