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A cannabinoid receptor 1 inverse agonist induces weight loss and reduces airway hyperresponsiveness in a mouse model of obese asthma.

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Title: A cannabinoid receptor 1 inverse agonist induces weight loss and reduces airway hyperresponsiveness in a mouse model of obese asthma.
Authors: Morris CR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Chandrasekaran R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Butzirus IM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Daphtary N; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Aliyeva M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Manuel AM; Mass Spectrometry and Proteomics Core, The University of Utah, Salt Lake City, Utah, United States., Tharp WG; Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Bates JHT; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Anathy V; Department of Pathology and Laboratory Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Poynter ME; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States., Duan J; Inversago Pharma Inc., Montreal, Quebec, Canada., Gaucher G; Inversago Pharma Inc., Montreal, Quebec, Canada., Crater GD; Inversago Pharma Inc., Montreal, Quebec, Canada., Dixon AE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.
Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2025 Sep 01; Vol. 329 (3), pp. L327-L340. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A cannabinoid receptor 1 inverse agonist induces weight loss and reduces airway hyperresponsiveness in a mouse model of obese asthma.
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  Data: <searchLink fieldCode="AU" term="%22Morris+CR%22">Morris CR</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Chandrasekaran+R%22">Chandrasekaran R</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Butzirus+IM%22">Butzirus IM</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Daphtary+N%22">Daphtary N</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Aliyeva+M%22">Aliyeva M</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Manuel+AM%22">Manuel AM</searchLink>; Mass Spectrometry and Proteomics Core, The University of Utah, Salt Lake City, Utah, United States.<br /><searchLink fieldCode="AU" term="%22Tharp+WG%22">Tharp WG</searchLink>; Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Bates+JHT%22">Bates JHT</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Anathy+V%22">Anathy V</searchLink>; Department of Pathology and Laboratory Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Poynter+ME%22">Poynter ME</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Inversago Pharma Inc., Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Gaucher+G%22">Gaucher G</searchLink>; Inversago Pharma Inc., Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Crater+GD%22">Crater GD</searchLink>; Inversago Pharma Inc., Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dixon+AE%22">Dixon AE</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States.
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              Text: 2025 Sep 01
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