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Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer.

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Title: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer.
Authors: Chang YC; TMU Research Center of Cancer Translational Medicine; Taipei Cancer Center, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 250, Wuxing Street, Taipei, 11031, Taiwan.; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan., Chen SJ; Department of Oncology, Neurosurgery, Albert Einstein College of Medicine, New York, NY, USA., Chen SH; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan., Hsiao SY; Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.; Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan., Chen LH; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan., Chen CH; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan., Liu CC; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan., Chen YW; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan., Liu KJ; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan., Wu SY; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan., Chu JM; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan., Qiu LY; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan., Chiang WF; Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan.; School of Dentistry, National Yang Ming University, Taipei, Taiwan., Hsieh HP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan., Hsueh WY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan., Hsiao JR; Department of Otolaryngology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan., Shen MR; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institue of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan., Chang JY; TMU Research Center of Cancer Translational Medicine; Taipei Cancer Center, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 250, Wuxing Street, Taipei, 11031, Taiwan. jychang@tmu.edu.tw.; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan. jychang@tmu.edu.tw., Chang KY; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan. kwang2@nhri.edu.tw.; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.
Source: Journal of biomedical science [J Biomed Sci] 2025 Jul 24; Vol. 32 (1), pp. 69. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chang+YC%22">Chang YC</searchLink>; TMU Research Center of Cancer Translational Medicine; Taipei Cancer Center, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 250, Wuxing Street, Taipei, 11031, Taiwan.; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SJ%22">Chen SJ</searchLink>; Department of Oncology, Neurosurgery, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+SH%22">Chen SH</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+SY%22">Hsiao SY</searchLink>; Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.; Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+LH%22">Chen LH</searchLink>; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CC%22">Liu CC</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YW%22">Chen YW</searchLink>; National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+KJ%22">Liu KJ</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+SY%22">Wu SY</searchLink>; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+JM%22">Chu JM</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.<br /><searchLink fieldCode="AU" term="%22Qiu+LY%22">Qiu LY</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+WF%22">Chiang WF</searchLink>; Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan.; School of Dentistry, National Yang Ming University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+HP%22">Hsieh HP</searchLink>; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsueh+WY%22">Hsueh WY</searchLink>; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+JR%22">Hsiao JR</searchLink>; Department of Otolaryngology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shen+MR%22">Shen MR</searchLink>; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institue of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+JY%22">Chang JY</searchLink>; TMU Research Center of Cancer Translational Medicine; Taipei Cancer Center, College of Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 250, Wuxing Street, Taipei, 11031, Taiwan. jychang@tmu.edu.tw.; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan. jychang@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chang+KY%22">Chang KY</searchLink>; National Institute of Cancer Research, National Health Research Institutes, 367 Sheng-Li Road, Tainan, 70456, Taiwan. kwang2@nhri.edu.tw.; Department of Oncology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. kwang2@nhri.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229421567%22">Journal of biomedical science</searchLink> [J Biomed Sci] 2025 Jul 24; Vol. 32 (1), pp. 69. <i>Date of Electronic Publication: </i>2025 Jul 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421567 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1423-0127 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210217770%22">10217770 </searchLink><i>NLM ISO Abbreviation: </i>J Biomed Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12929-025-01154-6
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              Text: 2025 Jul 24
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