Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.

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Title: Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.
Authors: Sherva R; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.; Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Zhu C; Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Zhang R; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA., Mez J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Hauger R; Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA., Merritt VC; Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA., Panizzon M; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla, CA, USA.; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA., Gaziano JM; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Catanzaro V; Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Pericak-Vance M; The Dr John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA., Haines JL; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Wang LS; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA., Mayeux R; Columbia University Department of Neurology, New York, NY, USA., Farrer LA; Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Bioinformatics Program, Boston University, Boston, MA, USA.; Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Logue MW; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA. loguem@bu.edu.; Biomedical Genetics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. loguem@bu.edu.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. loguem@bu.edu.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. loguem@bu.edu.
Corporate Authors: VA Million Veteran Program
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Jul 24; Vol. 17 (1), pp. 171. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1758-9193
DOI:10.1186/s13195-025-01782-y