BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir.

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Title: BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir.
Authors: Salinas TRW; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Harper J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Auger J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Flores HR; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Wilkes AC; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Stammen RL; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Tharp GK; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA., Kose E; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Laird GM; Accelevir Diagnostics, Baltimore, Maryland, USA., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Jones RB; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Badley AD; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Kulpa DA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Source: Research square [Res Sq] 2025 Jul 14. Date of Electronic Publication: 2025 Jul 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-7060088/v1