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BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir.

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Title: BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir.
Authors: Salinas TRW; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Harper J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Auger J; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Flores HR; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Wilkes AC; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Stammen RL; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Tharp GK; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA., Kose E; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Immonen TT; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Laird GM; Accelevir Diagnostics, Baltimore, Maryland, USA., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Jones RB; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Badley AD; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Kulpa DA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Source: Research square [Res Sq] 2025 Jul 14. Date of Electronic Publication: 2025 Jul 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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  Data: BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir.
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  Data: <searchLink fieldCode="AU" term="%22Salinas+TRW%22">Salinas TRW</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Harper+J%22">Harper J</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Deleage+C%22">Deleage C</searchLink>; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+K%22">Nguyen K</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Auger+J%22">Auger J</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Flores+HR%22">Flores HR</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wilkes+AC%22">Wilkes AC</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Stammen+RL%22">Stammen RL</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+JS%22">Wood JS</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tharp+GK%22">Tharp GK</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bosinger+SE%22">Bosinger SE</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+ML%22">Cottrell ML</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kose+E%22">Kose E</searchLink>; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Immonen+TT%22">Immonen TT</searchLink>; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lifson+JD%22">Lifson JD</searchLink>; 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Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kulpa+DA%22">Kulpa DA</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Paiardini+M%22">Paiardini M</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
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