Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity.

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Title: Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity.
Authors: Kozlovich SY; Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, 999 N. 92 Street, PO Box 1997, Milwaukee, WI, 53226, USA., Pan AY; Department of Pediatrics, Division of Bioinformatics and Quantitative Child Health, Medical College of Wisconsin, Milwaukee, WI, USA.; Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI, USA., McIntosh JJ; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Palatnik A; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Jia S; Department of Pediatrics, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI, USA., Hessner MJ; Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI, USA., Nghiem-Rao TH; Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, 999 N. 92 Street, PO Box 1997, Milwaukee, WI, 53226, USA. hnghiem@mcw.edu.
Source: Scientific reports [Sci Rep] 2025 Jul 25; Vol. 15 (1), pp. 27041. Date of Electronic Publication: 2025 Jul 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Hepatocyte reporter cells and integrated metabolomic and transcriptomic analyses reveal insights into hepatocyte changes in offspring of pregnancies with obesity.
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  Data: <searchLink fieldCode="AU" term="%22Kozlovich+SY%22">Kozlovich SY</searchLink>; Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, 999 N. 92 Street, PO Box 1997, Milwaukee, WI, 53226, USA.<br /><searchLink fieldCode="AU" term="%22Pan+AY%22">Pan AY</searchLink>; Department of Pediatrics, Division of Bioinformatics and Quantitative Child Health, Medical College of Wisconsin, Milwaukee, WI, USA.; Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22McIntosh+JJ%22">McIntosh JJ</searchLink>; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Palatnik+A%22">Palatnik A</searchLink>; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Jia+S%22">Jia S</searchLink>; Department of Pediatrics, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Hessner+MJ%22">Hessner MJ</searchLink>; Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Nghiem-Rao+TH%22">Nghiem-Rao TH</searchLink>; Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, 999 N. 92 Street, PO Box 1997, Milwaukee, WI, 53226, USA. hnghiem@mcw.edu.
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        Value: 10.1038/s41598-025-10808-2
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