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Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo-controlled trial with guselkumab.

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Title: Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo-controlled trial with guselkumab.
Authors: Rousel J; Centre for Human Drug Research, Leiden, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Bergmans ME; Centre for Human Drug Research, Leiden, the Netherlands., Bruijnincx LJ; Centre for Human Drug Research, Leiden, the Netherlands., Lin S; Centre for Human Drug Research, Leiden, the Netherlands., der Kolk TN; Centre for Human Drug Research, Leiden, the Netherlands., Bohoslavsky R; Centre for Human Drug Research, Leiden, the Netherlands., Yavuz Y; Centre for Human Drug Research, Leiden, the Netherlands., Klarenbeek NB; Centre for Human Drug Research, Leiden, the Netherlands., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Rissmann R; Centre for Human Drug Research, Leiden, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.; Leiden University Medical Centre, Leiden, the Netherlands., van Doorn MBA; Centre for Human Drug Research, Leiden, the Netherlands.; Erasmus Medical Centre, Rotterdam, the Netherlands.
Corporate Authors: Next‐Generation ImmunoDermatology Consortium (NGID)
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Dec; Vol. 91 (12), pp. 3378-3388. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo-controlled trial with guselkumab.
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  Data: <searchLink fieldCode="AU" term="%22Rousel+J%22">Rousel J</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bergmans+ME%22">Bergmans ME</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bruijnincx+LJ%22">Bruijnincx LJ</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22der+Kolk+TN%22">der Kolk TN</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bohoslavsky+R%22">Bohoslavsky R</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Yavuz+Y%22">Yavuz Y</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Klarenbeek+NB%22">Klarenbeek NB</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouwstra+JA%22">Bouwstra JA</searchLink>; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rissmann+R%22">Rissmann R</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.; Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Doorn+MBA%22">van Doorn MBA</searchLink>; Centre for Human Drug Research, Leiden, the Netherlands.; Erasmus Medical Centre, Rotterdam, the Netherlands.
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  Data: <searchLink fieldCode="CA" term="%22Next‐Generation+ImmunoDermatology+Consortium+%28NGID%29%22">Next‐Generation ImmunoDermatology Consortium (NGID)</searchLink>
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2025 Dec; Vol. 91 (12), pp. 3378-3388. <i>Date of Electronic Publication: </i>2025 Jul 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7503323 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2125 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203065251%22">03065251 </searchLink><i>NLM ISO Abbreviation: </i>Br J Clin Pharmacol <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec
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