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A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.

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Title: A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.
Authors: Benedetto SR; Neurocrine Biosciences Inc., San Diego, CA., Ionescu A; Neurocrine Biosciences Inc., San Diego, CA., Ge T; Neurocrine Biosciences Inc., San Diego, CA., Furey M; Neurocrine Biosciences Inc., San Diego, CA., Lin S; Neurocrine Biosciences Inc., San Diego, CA., Jha MK; Department of Psychiatry and Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX., Krystal A; Department of Psychiatry, University of California, San Francisco, San Francisco, CA., Shah AA; Department of Psychiatry, Baylor College of Medicine, Houston, TX., Walling DP; CenExel CNS, Garden Grove, CA., Shah N; Neurocrine Biosciences Inc., San Diego, CA., Rizvi SJ; ASR Suicide and Depression Studies Program, St. Michael's Hospital, Toronto, Canada., Kennedy S; ASR Suicide and Depression Studies Program, St. Michael's Hospital, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada., Laurenza A; Takeda Pharmaceutical Company Limited, Cambridge, MA., Murthy V; Takeda Pharmaceutical Company Limited, Cambridge, MA., Roberts E; Neurocrine Biosciences Inc., San Diego, CA., Singh JB; Neurocrine Biosciences Inc., San Diego, CA.
Source: Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2025 Sep-Oct 01; Vol. 45 (5), pp. 432-440. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Williams And Wilkins Country of Publication: United States NLM ID: 8109496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-712X (Electronic) Linking ISSN: 02710749 NLM ISO Abbreviation: J Clin Psychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.
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  Data: <searchLink fieldCode="AU" term="%22Benedetto+SR%22">Benedetto SR</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Ionescu+A%22">Ionescu A</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Ge+T%22">Ge T</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Furey+M%22">Furey M</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Jha+MK%22">Jha MK</searchLink>; Department of Psychiatry and Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Krystal+A%22">Krystal A</searchLink>; Department of Psychiatry, University of California, San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Shah+AA%22">Shah AA</searchLink>; Department of Psychiatry, Baylor College of Medicine, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Walling+DP%22">Walling DP</searchLink>; CenExel CNS, Garden Grove, CA.<br /><searchLink fieldCode="AU" term="%22Shah+N%22">Shah N</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Rizvi+SJ%22">Rizvi SJ</searchLink>; ASR Suicide and Depression Studies Program, St. Michael's Hospital, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Kennedy+S%22">Kennedy S</searchLink>; ASR Suicide and Depression Studies Program, St. Michael's Hospital, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Laurenza+A%22">Laurenza A</searchLink>; Takeda Pharmaceutical Company Limited, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Murthy+V%22">Murthy V</searchLink>; Takeda Pharmaceutical Company Limited, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Roberts+E%22">Roberts E</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Singh+JB%22">Singh JB</searchLink>; Neurocrine Biosciences Inc., San Diego, CA.
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  Data: <searchLink fieldCode="JN" term="%228109496%22">Journal of clinical psychopharmacology</searchLink> [J Clin Psychopharmacol] 2025 Sep-Oct 01; Vol. 45 (5), pp. 432-440. <i>Date of Electronic Publication: </i>2025 Jul 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Williams+And+Wilkins%22">Williams And Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8109496 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1533-712X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202710749%22">02710749 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Psychopharmacol <i>Subsets: </i>MEDLINE
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              Text: 2025 Sep-Oct 01
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