Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst.
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| Title: | Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst. |
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| Authors: | Simon CS; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., McCarthy A; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Woods L; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Staneva D; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Proks M; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Salehin N; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Lea G; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Huang Q; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Linneberg-Agerholm M; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Faulkner A; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK., Papathanasiou A; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Elder K; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Snell P; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Christie L; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Garcia P; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Shaikly V; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Taranissi M; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Choudhary M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK., Herbert M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.; Department of Anatomy & Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia., Hanna CW; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Brickman JM; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Niakan KK; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. kkn21@cam.ac.uk.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. kkn21@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK. kkn21@cam.ac.uk.; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. kkn21@cam.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Jul 28; Vol. 16 (1), pp. 6922. Date of Electronic Publication: 2025 Jul 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-61830-x |
