Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst.
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| Title: | Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst. |
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| Authors: | Simon CS; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., McCarthy A; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Woods L; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Staneva D; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Proks M; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Salehin N; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Lea G; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Huang Q; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Linneberg-Agerholm M; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Faulkner A; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK., Papathanasiou A; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Elder K; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Snell P; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Christie L; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK., Garcia P; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Shaikly V; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Taranissi M; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK., Choudhary M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK., Herbert M; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.; Department of Anatomy & Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia., Hanna CW; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK., Brickman JM; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Niakan KK; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. kkn21@cam.ac.uk.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. kkn21@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK. kkn21@cam.ac.uk.; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. kkn21@cam.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Jul 28; Vol. 16 (1), pp. 6922. Date of Electronic Publication: 2025 Jul 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40721412 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Simon+CS%22">Simon CS</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+A%22">McCarthy A</searchLink>; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Woods+L%22">Woods L</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.<br /><searchLink fieldCode="AU" term="%22Staneva+D%22">Staneva D</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.<br /><searchLink fieldCode="AU" term="%22Proks+M%22">Proks M</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Salehin+N%22">Salehin N</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lea+G%22">Lea G</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Linneberg-Agerholm+M%22">Linneberg-Agerholm M</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Faulkner+A%22">Faulkner A</searchLink>; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Papathanasiou+A%22">Papathanasiou A</searchLink>; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Elder+K%22">Elder K</searchLink>; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Snell+P%22">Snell P</searchLink>; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Christie+L%22">Christie L</searchLink>; Bourn Hall Clinic, Bourn, Cambridge, CB23 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+P%22">Garcia P</searchLink>; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK.<br /><searchLink fieldCode="AU" term="%22Shaikly+V%22">Shaikly V</searchLink>; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK.<br /><searchLink fieldCode="AU" term="%22Taranissi+M%22">Taranissi M</searchLink>; Assisted Reproduction and Gynaecology Centre, London, W1G 6LP, UK.<br /><searchLink fieldCode="AU" term="%22Choudhary+M%22">Choudhary M</searchLink>; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Herbert+M%22">Herbert M</searchLink>; Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.; Department of Anatomy & Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Hanna+CW%22">Hanna CW</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.<br /><searchLink fieldCode="AU" term="%22Brickman+JM%22">Brickman JM</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Niakan+KK%22">Niakan KK</searchLink>; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. kkn21@cam.ac.uk.; Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. kkn21@cam.ac.uk.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK. kkn21@cam.ac.uk.; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. kkn21@cam.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 28; Vol. 16 (1), pp. 6922. <i>Date of Electronic Publication: </i>2025 Jul 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40721412 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-61830-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 6922 Titles: – TitleFull: Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Simon CS – PersonEntity: Name: NameFull: McCarthy A – PersonEntity: Name: NameFull: Woods L – PersonEntity: Name: NameFull: Staneva D – PersonEntity: Name: NameFull: Proks M – PersonEntity: Name: NameFull: Salehin N – PersonEntity: Name: NameFull: Lea G – PersonEntity: Name: NameFull: Huang Q – PersonEntity: Name: NameFull: Linneberg-Agerholm M – PersonEntity: Name: NameFull: Faulkner A – PersonEntity: Name: NameFull: Papathanasiou A – PersonEntity: Name: NameFull: Elder K – PersonEntity: Name: NameFull: Snell P – PersonEntity: Name: NameFull: Christie L – PersonEntity: Name: NameFull: Garcia P – PersonEntity: Name: NameFull: Shaikly V – PersonEntity: Name: NameFull: Taranissi M – PersonEntity: Name: NameFull: Choudhary M – PersonEntity: Name: NameFull: Herbert M – PersonEntity: Name: NameFull: Hanna CW – PersonEntity: Name: NameFull: Brickman JM – PersonEntity: Name: NameFull: Niakan KK IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 07 Text: 2025 Jul 28 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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