Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization.

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Title: Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization.
Authors: Kollotzek F; DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of Tübingen, Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany., Mott K; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany., Fischer M; DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of Tübingen, Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany., Findik B; Department of Hematology, Oncology, Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.; Faculty of Medicine University Tübingen, Gene and RNA Therapy Center, Tübingen, Germany., Göb V; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany.; Rudolf Virchow Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Manke MC; DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of Tübingen, Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany., Borst CE; Department of Hematology, Oncology, Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany., Polzin A; Department of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Düsseldorf, Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Burkhalter MD; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-Universität Tübingen, Tübingen, Germany., Eckly A; University of Strasbourg, INSERM, Etablissement Français du Sang Grand-Est, Unité Mixte de Recherche (UMR S1255) Biologie et Pharmacologie des Plaquettes Sanguines, Translational Medicine Federation of Strasbourg, Strasbourg, France., Bakchoul T; Centre for Clinical Transfusion Medicine, University Hospital of Tübingen, Tübingen, Germany., Philipp M; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-Universität Tübingen, Tübingen, Germany., Holzmayer SJ; German Cancer Consortium (DKTK partner site Tübingen), a partnership between the German Cancer Research Center and University Hospital Tübingen, Tübingen, Germany.; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Quintanilla-Fend L; Institute for Pathology, Department of General and Molecular Pathology, University Hospital Tübingen, Tübingen, Germany., Lengerke C; Department of Hematology, Oncology, Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany., Gawaz M; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany., Leon C; University of Strasbourg, INSERM, Etablissement Français du Sang Grand-Est, Unité Mixte de Recherche (UMR S1255) Biologie et Pharmacologie des Plaquettes Sanguines, Translational Medicine Federation of Strasbourg, Strasbourg, France., Stegner D; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany.; Rudolf Virchow Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Nieswandt B; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany.; Rudolf Virchow Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Vainchenker W; INSERM, UMR 1287, Gustave Roussy, Equipe labellisée Ligue Nationale Contre le Cancer, Villejuif, France.; Université Paris-Saclay, Gif-sur-Yvette, France.; Gustave Roussy, Villejuif, France., Bender M; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany., Skokowa J; Department of Hematology, Oncology, Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.; Faculty of Medicine University Tübingen, Gene and RNA Therapy Center, Tübingen, Germany.; Severe Chronic Neutropenia International Registry, Department of Hematology, Oncology, Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany., Schulze H; Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany., Münzer P; DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of Tübingen, Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany., Borst O; DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of Tübingen, Tübingen, Germany.; Department of Cardiology and Angiology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies (iFIT),' University of Tübingen, Tübingen, Germany.
Source: Blood [Blood] 2025 Oct 16; Vol. 146 (16), pp. 1964-1978.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-0020
DOI:10.1182/blood.2025028460