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Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner.

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Title: Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner.
Authors: Roy ER; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Ethan.R.Roy@uth.tmc.edu.; University of Texas Health Science Center at Houston, 77030, Houston, TX, USA. Ethan.R.Roy@uth.tmc.edu., Wang Q; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Huang K; McWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA., Li S; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Fan Y; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Escobar E; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Atkins CL; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Huang S; Department of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Herrera JJ; Department of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Li W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Pridans C; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Zhou X; McWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA., Ju C; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Cao W; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Wei.Cao@uth.tmc.edu.; University of Texas Health Science Center at Houston, 77030, Houston, TX, USA. Wei.Cao@uth.tmc.edu.
Source: Scientific reports [Sci Rep] 2025 Jul 29; Vol. 15 (1), pp. 27664. Date of Electronic Publication: 2025 Jul 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner.
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  Data: <searchLink fieldCode="AU" term="%22Roy+ER%22">Roy ER</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Ethan.R.Roy@uth.tmc.edu.; University of Texas Health Science Center at Houston, 77030, Houston, TX, USA. Ethan.R.Roy@uth.tmc.edu.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+K%22">Huang K</searchLink>; McWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Escobar+E%22">Escobar E</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Atkins+CL%22">Atkins CL</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Herrera+JJ%22">Herrera JJ</searchLink>; Department of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pridans+C%22">Pridans C</searchLink>; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; McWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ju+C%22">Ju C</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cao+W%22">Cao W</searchLink>; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Wei.Cao@uth.tmc.edu.; University of Texas Health Science Center at Houston, 77030, Houston, TX, USA. Wei.Cao@uth.tmc.edu.
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