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Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri.

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Title: Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri.
Authors: Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea., Lê HG; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Võ TC; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Kim M; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea., No JH; Chemical and Structural Biology of Pathogens, Institut Pasteur Korea, Seongnam-si 13488, Republic of Korea., Aboutaleb MH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt., Sim J; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea., Na BK; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Lee YS; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2025 Jun 30; Vol. 18 (7). Date of Electronic Publication: 2025 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri.
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  Data: <searchLink fieldCode="AU" term="%22Hassan+AHE%22">Hassan AHE</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lê+HG%22">Lê HG</searchLink>; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Võ+TC%22">Võ TC</searchLink>; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22No+JH%22">No JH</searchLink>; Chemical and Structural Biology of Pathogens, Institut Pasteur Korea, Seongnam-si 13488, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Aboutaleb+MH%22">Aboutaleb MH</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt.<br /><searchLink fieldCode="AU" term="%22Sim+J%22">Sim J</searchLink>; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Na+BK%22">Na BK</searchLink>; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101238453%22">Pharmaceuticals (Basel, Switzerland)</searchLink> [Pharmaceuticals (Basel)] 2025 Jun 30; Vol. 18 (7). <i>Date of Electronic Publication: </i>2025 Jun 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101238453 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1424-8247 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214248247%22">14248247 </searchLink><i>NLM ISO Abbreviation: </i>Pharmaceuticals (Basel) <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Jun 30
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