Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide.

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Title: Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide.
Authors: Yonker LM; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kane AS; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Swank Z; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Papadakis L; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA., Kenyon V; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Han S; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Lima R; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Guthrie LB; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Alvarez-Carcamo B; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Lahoud-Rahme M; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Balaguru D; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Carroll RW; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lok J; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., El Saleeby C; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Walt DR; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Fasano A; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eadu4284. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adu4284