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Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide.

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Title: Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide.
Authors: Yonker LM; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kane AS; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Swank Z; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Papadakis L; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA., Kenyon V; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Han S; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Lima R; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Guthrie LB; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Alvarez-Carcamo B; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA., Lahoud-Rahme M; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Balaguru D; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Carroll RW; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lok J; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., El Saleeby C; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Walt DR; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Fasano A; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eadu4284. Date of Electronic Publication: 2025 Jul 30.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide.
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  Data: <searchLink fieldCode="AU" term="%22Yonker+LM%22">Yonker LM</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kane+AS%22">Kane AS</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Swank+Z%22">Swank Z</searchLink>; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Papadakis+L%22">Papadakis L</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kenyon+V%22">Kenyon V</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lima+R%22">Lima R</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guthrie+LB%22">Guthrie LB</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez-Carcamo+B%22">Alvarez-Carcamo B</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lahoud-Rahme+M%22">Lahoud-Rahme M</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Balaguru+D%22">Balaguru D</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+RW%22">Carroll RW</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lok+J%22">Lok J</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22El+Saleeby+C%22">El Saleeby C</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walt+DR%22">Walt DR</searchLink>; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fasano+A%22">Fasano A</searchLink>; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Jul 30; Vol. 17 (809), pp. eadu4284. <i>Date of Electronic Publication: </i>2025 Jul 30.
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