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Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells.

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Title: Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells.
Authors: Kim SG; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Yoon DJ; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Varias DC; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Ahn GJ; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Han GU; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Moon SH; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Lee HS; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Shin SH; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea., Ryu BY; Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-Do 17546, Republic of Korea. Electronic address: byryu@cau.ac.kr.
Source: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Sep; Vol. 213, pp. 106486. Date of Electronic Publication: 2025 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-9939
DOI:10.1016/j.pestbp.2025.106486