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A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.

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Title: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.
Authors: Apfelbaum AA; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Morin E; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden., Sturm D; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Ayoub G; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., DiGiacomo J; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bahadur S; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chandarana B; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Power PC; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Cusick MM; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Novikov D; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Prabhakar P; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Jones RE; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Vogelzang J; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Bossi CC; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Malinowski S; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Woodward LM; Blizard Institute, Queen Mary University of London, London, UK., Jones TA; Blizard Institute, Queen Mary University of London, London, UK., Jeang J; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lamson SW; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins J; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cai KY; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jones JS; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Oh S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Jeon H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Cameron A; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rechter P; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., De Leon A; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Murugesan K; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA., Montesion M; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA., Albacker LA; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA., Ramkissoon SH; Pathology, Foundation Medicine Inc, Boston, MA, USA.; Labcorp Oncology, Durham, NC, USA.; Wake Forest Comprehensive Cancer Center and Department of Pathology, Winston-, Salem, NC, USA., van Tilburg CM; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hardin EC; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sievers P; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research, Heidelberg, Germany, Heidelberg, Germany., Sahm F; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research, Heidelberg, Germany, Heidelberg, Germany., Yeo KK; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Rosenberg T; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Chi SN; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Wright KD; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA., Hébert S; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada., Peck S; Orlando Health- Arnold Palmer Hospital for Children, Orlando, FL, USA., Picca A; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau - Paris Brain Institute (ICM), AP-HP, Pitié Salpêtrière University Hospital, Paris, France., Larouche V; Department of Pediatrics, Hemato-Oncology, CHU de Québec-Université Laval, Quebec City, QC, Canada., Renzi S; Division of Pediatric Hematology-Oncology, Chul-Québec, Quebec City, QC, Canada., Buhrlage SJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Bale TA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Smith AA; Orlando Health- Arnold Palmer Hospital for Children, Orlando, FL, USA., Touat M; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau - Paris Brain Institute (ICM), AP-HP, Pitié Salpêtrière University Hospital, Paris, France., Jabado N; Department of Human Genetics, McGill University, Montreal, QC, Canada., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Baird L; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Harvard University, Boston, MA, USA., Witt O; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kleinman CL; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Sheer D; Blizard Institute, Queen Mary University of London, London, UK., Alexandrescu S; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Harvard University, Boston, MA, USA., Jones DTW; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Boston Children's Hospital, Harvard University, Boston, MA, USA. keith_ligon@dfci.harvard.edu., Bandopadhayay P; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.
Source: Nature communications [Nat Commun] 2025 Jul 31; Vol. 16 (1), pp. 7018. Date of Electronic Publication: 2025 Jul 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.
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  Data: <searchLink fieldCode="AU" term="%22Apfelbaum+AA%22">Apfelbaum AA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morin+E%22">Morin E</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Sturm+D%22">Sturm D</searchLink>; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ayoub+G%22">Ayoub G</searchLink>; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22DiGiacomo+J%22">DiGiacomo J</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bahadur+S%22">Bahadur S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; 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Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lamson+SW%22">Lamson SW</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collins+J%22">Collins J</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+KY%22">Cai KY</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+JS%22">Jones JS</searchLink>; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jeon+H%22">Jeon H</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+A%22">Cameron A</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rechter+P%22">Rechter P</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22De+Leon+A%22">De Leon A</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Murugesan+K%22">Murugesan K</searchLink>; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Montesion+M%22">Montesion M</searchLink>; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Albacker+LA%22">Albacker LA</searchLink>; Computational Discovery, Foundation Medicine Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ramkissoon+SH%22">Ramkissoon SH</searchLink>; Pathology, Foundation Medicine Inc, Boston, MA, USA.; Labcorp Oncology, Durham, NC, USA.; Wake Forest Comprehensive Cancer Center and Department of Pathology, Winston-, Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22van+Tilburg+CM%22">van Tilburg CM</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hardin+EC%22">Hardin EC</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sievers+P%22">Sievers P</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research, Heidelberg, Germany, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sahm+F%22">Sahm F</searchLink>; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research, Heidelberg, Germany, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Yeo+KK%22">Yeo KK</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+T%22">Rosenberg T</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chi+SN%22">Chi SN</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wright+KD%22">Wright KD</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hébert+S%22">Hébert S</searchLink>; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Peck+S%22">Peck S</searchLink>; Orlando Health- Arnold Palmer Hospital for Children, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Picca+A%22">Picca A</searchLink>; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau - Paris Brain Institute (ICM), AP-HP, Pitié Salpêtrière University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Larouche+V%22">Larouche V</searchLink>; Department of Pediatrics, Hemato-Oncology, CHU de Québec-Université Laval, Quebec City, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Renzi+S%22">Renzi S</searchLink>; Division of Pediatric Hematology-Oncology, Chul-Québec, Quebec City, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Buhrlage+SJ%22">Buhrlage SJ</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bale+TA%22">Bale TA</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smith+AA%22">Smith AA</searchLink>; Orlando Health- Arnold Palmer Hospital for Children, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Touat+M%22">Touat M</searchLink>; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau - Paris Brain Institute (ICM), AP-HP, Pitié Salpêtrière University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jabado+N%22">Jabado N</searchLink>; Department of Human Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Fischer+ES%22">Fischer ES</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eck+MJ%22">Eck MJ</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Baird+L%22">Baird L</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kleinman+CL%22">Kleinman CL</searchLink>; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nguyen+QD%22">Nguyen QD</searchLink>; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sheer+D%22">Sheer D</searchLink>; Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Alexandrescu+S%22">Alexandrescu S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ligon+KL%22">Ligon KL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. keith_ligon@dfci.harvard.edu.; Department of Pathology, Boston Children's Hospital, Harvard University, Boston, MA, USA. keith_ligon@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Bandopadhayay+P%22">Bandopadhayay P</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jul 31; Vol. 16 (1), pp. 7018. <i>Date of Electronic Publication: </i>2025 Jul 31.
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      – TitleFull: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.
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            – D: 31
              M: 07
              Text: 2025 Jul 31
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
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              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
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