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NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.

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Title: NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.
Authors: Singh I; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Department of Medicine, Technische Universität München, Munich, Germany., Onogi Y; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Research Center for Pre-Disease Science (RCPDS), University of Toyama, Sugitani 2630, Toyama, 9300194, Japan., Menezes F; Molecular Targets and Therapeutics Center, Institute of Structural Biology, Neuherberg, 85764, Germany., Khasanova D; Molecular Targets and Therapeutics Center, Institute of Structural Biology, Neuherberg, 85764, Germany., Kang L; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Wang C; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Ruiz-Trave J; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Center Munich, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany., Sharma S; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, 85764, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Khalil A; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Center Munich, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany., Reichenbach VK; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Shi Y; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Flatley A; Core Facility Monoclonal Antibodies (CF-MAB), Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany., Yan X; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Israel A; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Dragano NRV; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany., Aguilar-Pimentel JA; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Ghosh A; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, 8092, Switzerland., Noé F; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, 8092, Switzerland., Wolfrum C; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, 8092, Switzerland., Cucuruz S; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Zentrum Munich, Neuherberg, 85764, Germany., König AC; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Burtscher I; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Hauck SM; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Lickert H; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Zentrum Munich, Neuherberg, 85764, Germany., Hofmann SM; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Zentrum Munich, Neuherberg, 85764, Germany.; Department of Medicine IV, University Hospital, Ludwig-Maximilians University, Munich, Germany., Feederle R; Core Facility Monoclonal Antibodies (CF-MAB), Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Straße 17, Munich, D-81377, Germany., Schriever SC; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany., Hernandez-Bautista R; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany., Sancar G; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University of Tübingen, Tübingen, Germany., Cebrian-Serrano A; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Center Munich, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany., Tetko I; Molecular Targets and Therapeutics Center, Institute of Structural Biology, Neuherberg, 85764, Germany., Fuchs H; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany., Gailus-Durner V; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany., Blüher M; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, 04103, Germany., Hrabě de Angelis M; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, Technische Universität München, Freising, 85354, Germany., Ussar S; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, 85764, Germany. siegfried.ussar@helmholtz-munich.de.; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany. siegfried.ussar@helmholtz-munich.de.
Source: The EMBO journal [EMBO J] 2025 Sep; Vol. 44 (18), pp. 5037-5065. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00520-2