Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects.

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Title: Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects.
Authors: Nochi Z; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pia H; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Bloms-Funke P; Translational Science and Intelligence, Grünenthal GmbH, Aachen, Germany., Boesl I; Grünenthal GmbH, Aachen, Germany., Caspani O; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Chapman SC; Eli Lilly and Company, Bracknell, United Kingdom., Di Pietro G; Department of Human Neuroscience, Sapienza University, Rome, Italy., Fardo F; Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Genser B; High5Data GmbH, Heidelberg, Germany., Goetz M; MRC Systems GmbH, Heidelberg, Germany., Jiang B; Teva Branded Pharmaceutical Products R&D, Inc, West Chester, Pennsylvania., Kostenko AV; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Lebrun L; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Leone CM; Department of Human Neuroscience, Sapienza University, Rome, Italy., Li T; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania., Möller-Grell N; Central Institute of Mental Health (CIMH), Mannheim, Germany., Mouraux A; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Pelz B; MRC Systems GmbH, Heidelberg, Germany., Pogatzki-Zahn E; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Rong C; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania., Schilder A; Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schnetter E; Heidelberg University Computer Center, Heidelberg, Germany., Schubart K; ConsulTech GmbH, Berlin, Germany., Tracey I; Wellcome Centre for Integrative Neuroimaging, Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Truini A; Department of Human Neuroscience, Sapienza University, Rome, Italy., Vincent K; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom., Vollert J; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom., Wanigasekera V; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Wittayer M; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Treede RD; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Tankisi H; Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Finnerup NB; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Source: Anesthesiology [Anesthesiology] 2025 Nov 01; Vol. 143 (5), pp. 1279-1295. Date of Electronic Publication: 2025 Aug 04.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-1175
DOI:10.1097/ALN.0000000000005694