Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects.
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| Title: | Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects. |
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| Authors: | Nochi Z; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pia H; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Bloms-Funke P; Translational Science and Intelligence, Grünenthal GmbH, Aachen, Germany., Boesl I; Grünenthal GmbH, Aachen, Germany., Caspani O; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Chapman SC; Eli Lilly and Company, Bracknell, United Kingdom., Di Pietro G; Department of Human Neuroscience, Sapienza University, Rome, Italy., Fardo F; Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Genser B; High5Data GmbH, Heidelberg, Germany., Goetz M; MRC Systems GmbH, Heidelberg, Germany., Jiang B; Teva Branded Pharmaceutical Products R&D, Inc, West Chester, Pennsylvania., Kostenko AV; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Lebrun L; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Leone CM; Department of Human Neuroscience, Sapienza University, Rome, Italy., Li T; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania., Möller-Grell N; Central Institute of Mental Health (CIMH), Mannheim, Germany., Mouraux A; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Pelz B; MRC Systems GmbH, Heidelberg, Germany., Pogatzki-Zahn E; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Rong C; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania., Schilder A; Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schnetter E; Heidelberg University Computer Center, Heidelberg, Germany., Schubart K; ConsulTech GmbH, Berlin, Germany., Tracey I; Wellcome Centre for Integrative Neuroimaging, Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Truini A; Department of Human Neuroscience, Sapienza University, Rome, Italy., Vincent K; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom., Vollert J; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom., Wanigasekera V; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Wittayer M; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Treede RD; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany., Tankisi H; Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Finnerup NB; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
| Source: | Anesthesiology [Anesthesiology] 2025 Nov 01; Vol. 143 (5), pp. 1279-1295. Date of Electronic Publication: 2025 Aug 04. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40758952 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nochi+Z%22">Nochi Z</searchLink>; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Pia+H%22">Pia H</searchLink>; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bloms-Funke+P%22">Bloms-Funke P</searchLink>; Translational Science and Intelligence, Grünenthal GmbH, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Boesl+I%22">Boesl I</searchLink>; Grünenthal GmbH, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Caspani+O%22">Caspani O</searchLink>; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Chapman+SC%22">Chapman SC</searchLink>; Eli Lilly and Company, Bracknell, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Di+Pietro+G%22">Di Pietro G</searchLink>; Department of Human Neuroscience, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fardo+F%22">Fardo F</searchLink>; Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Genser+B%22">Genser B</searchLink>; High5Data GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Goetz+M%22">Goetz M</searchLink>; MRC Systems GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jiang+B%22">Jiang B</searchLink>; Teva Branded Pharmaceutical Products R&D, Inc, West Chester, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kostenko+AV%22">Kostenko AV</searchLink>; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Lebrun+L%22">Lebrun L</searchLink>; Institute of Neuroscience, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Leone+CM%22">Leone CM</searchLink>; Department of Human Neuroscience, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Möller-Grell+N%22">Möller-Grell N</searchLink>; Central Institute of Mental Health (CIMH), Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Mouraux+A%22">Mouraux A</searchLink>; Institute of Neuroscience, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Pelz+B%22">Pelz B</searchLink>; MRC Systems GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pogatzki-Zahn+E%22">Pogatzki-Zahn E</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Rong+C%22">Rong C</searchLink>; Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Schilder+A%22">Schilder A</searchLink>; Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schnetter+E%22">Schnetter E</searchLink>; Heidelberg University Computer Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schubart+K%22">Schubart K</searchLink>; ConsulTech GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tracey+I%22">Tracey I</searchLink>; Wellcome Centre for Integrative Neuroimaging, Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Truini+A%22">Truini A</searchLink>; Department of Human Neuroscience, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vincent+K%22">Vincent K</searchLink>; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vollert+J%22">Vollert J</searchLink>; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wanigasekera+V%22">Wanigasekera V</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wittayer+M%22">Wittayer M</searchLink>; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Treede+RD%22">Treede RD</searchLink>; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Tankisi+H%22">Tankisi H</searchLink>; Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Finnerup+NB%22">Finnerup NB</searchLink>; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221300217%22">Anesthesiology</searchLink> [Anesthesiology] 2025 Nov 01; Vol. 143 (5), pp. 1279-1295. <i>Date of Electronic Publication: </i>2025 Aug 04. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1300217 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1175 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200033022%22">00033022 </searchLink><i>NLM ISO Abbreviation: </i>Anesthesiology <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40758952 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1097/ALN.0000000000005694 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1279 Titles: – TitleFull: Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nochi Z – PersonEntity: Name: NameFull: Pia H – PersonEntity: Name: NameFull: Bloms-Funke P – PersonEntity: Name: NameFull: Boesl I – PersonEntity: Name: NameFull: Caspani O – PersonEntity: Name: NameFull: Chapman SC – PersonEntity: Name: NameFull: Di Pietro G – PersonEntity: Name: NameFull: Fardo F – PersonEntity: Name: NameFull: Genser B – PersonEntity: Name: NameFull: Goetz M – PersonEntity: Name: NameFull: Jiang B – PersonEntity: Name: NameFull: Kostenko AV – PersonEntity: Name: NameFull: Lebrun L – PersonEntity: Name: NameFull: Leone CM – PersonEntity: Name: NameFull: Li T – PersonEntity: Name: NameFull: Möller-Grell N – PersonEntity: Name: NameFull: Mouraux A – PersonEntity: Name: NameFull: Pelz B – PersonEntity: Name: NameFull: Pogatzki-Zahn E – PersonEntity: Name: NameFull: Rong C – PersonEntity: Name: NameFull: Schilder A – PersonEntity: Name: NameFull: Schnetter E – PersonEntity: Name: NameFull: Schubart K – PersonEntity: Name: NameFull: Tracey I – PersonEntity: Name: NameFull: Truini A – PersonEntity: Name: NameFull: Vincent K – PersonEntity: Name: NameFull: Vollert J – PersonEntity: Name: NameFull: Wanigasekera V – PersonEntity: Name: NameFull: Wittayer M – PersonEntity: Name: NameFull: Treede RD – PersonEntity: Name: NameFull: Tankisi H – PersonEntity: Name: NameFull: Finnerup NB IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2025 Nov 01 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1528-1175 Numbering: – Type: volume Value: 143 – Type: issue Value: 5 Titles: – TitleFull: Anesthesiology Type: main |
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