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Promising efficacy of oral nano-silymarin formulation on prevention of vancomycin-induced nephrotoxicity: a randomized, triple-blinded, placebo-controlled clinical trial.

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Title: Promising efficacy of oral nano-silymarin formulation on prevention of vancomycin-induced nephrotoxicity: a randomized, triple-blinded, placebo-controlled clinical trial.
Authors: Soleimani V; Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box, Mashhad, 91775-1365, Iran.; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran., Khodashahi R; Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran., Arian M; Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran., Tavanaee A; Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran., Omidkhoda N; Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box, Mashhad, 91775-1365, Iran., Karimi G; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. karimig@mums.ac.ir.; Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box, Mashhad, 91775-1365, Iran. karimig@mums.ac.ir., Elyasi S; Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box, Mashhad, 91775-1365, Iran. elyasis@mums.ac.ir.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jan; Vol. 399 (1), pp. 1249-1261. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1912
DOI:10.1007/s00210-025-04469-1