Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function.
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| Title: | Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function. |
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| Authors: | Barisa M; Great Ormond Street Institute of Child Health, University College London, London, UK. m.barisa@ucl.ac.uk., Muller HP; Great Ormond Street Institute of Child Health, University College London, London, UK., Zappa E; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Shah R; Great Ormond Street Institute of Child Health, University College London, London, UK., Buhl JL; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Draper B; Great Ormond Street Institute of Child Health, University College London, London, UK., Himsworth C; Great Ormond Street Institute of Child Health, University College London, London, UK., Bowers C; Great Ormond Street Institute of Child Health, University College London, London, UK., Munnings-Tomes S; Great Ormond Street Institute of Child Health, University College London, London, UK., Nicolaidou M; Great Ormond Street Institute of Child Health, University College London, London, UK., Morlando S; Great Ormond Street Institute of Child Health, University College London, London, UK., Birley K; Great Ormond Street Institute of Child Health, University College London, London, UK., Leboreiro-Babe C; Great Ormond Street Institute of Child Health, University College London, London, UK., Vitali A; Great Ormond Street Institute of Child Health, University College London, London, UK., Privitera L; Great Ormond Street Institute of Child Health, University College London, London, UK., O'Sullivan K; Great Ormond Street Institute of Child Health, University College London, London, UK., Greppi A; Great Ormond Street Institute of Child Health, University College London, London, UK., Buschhaus M; Lumicks, Amsterdam, The Netherlands., Román MB; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., de Blank S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van den Ham F; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van 't Veld BR; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Ferry G; Great Ormond Street Institute of Child Health, University College London, London, UK., Fisher J; Great Ormond Street Institute of Child Health, University College London, London, UK., Shome D; Lumicks, Amsterdam, The Netherlands., Nadafi R; Lumicks, Amsterdam, The Netherlands., Ansari IH; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Reijmers R; Lumicks, Amsterdam, The Netherlands., Giuliani S; Great Ormond Street Institute of Child Health, University College London, London, UK., Sondel P; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Donovan LK; Great Ormond Street Institute of Child Health, University College London, London, UK., Chesler L; Cancer Institute, University College London, London, UK., Jan Molenaar; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Drost J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Rios AC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Chester K; The Institute of Cancer Research, London, UK., Wienke J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. j.wienke-4@prinsesmaximacentrum.nl., Anderson J; Great Ormond Street Institute of Child Health, University College London, London, UK. j.anderson@ucl.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Aug 05; Vol. 16 (1), pp. 7196. Date of Electronic Publication: 2025 Aug 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-61427-4 |
