View in EDS HTML Full Text PDF Full Text

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function.

Saved in:
Bibliographic Details
Title: Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function.
Authors: Barisa M; Great Ormond Street Institute of Child Health, University College London, London, UK. m.barisa@ucl.ac.uk., Muller HP; Great Ormond Street Institute of Child Health, University College London, London, UK., Zappa E; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Shah R; Great Ormond Street Institute of Child Health, University College London, London, UK., Buhl JL; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Draper B; Great Ormond Street Institute of Child Health, University College London, London, UK., Himsworth C; Great Ormond Street Institute of Child Health, University College London, London, UK., Bowers C; Great Ormond Street Institute of Child Health, University College London, London, UK., Munnings-Tomes S; Great Ormond Street Institute of Child Health, University College London, London, UK., Nicolaidou M; Great Ormond Street Institute of Child Health, University College London, London, UK., Morlando S; Great Ormond Street Institute of Child Health, University College London, London, UK., Birley K; Great Ormond Street Institute of Child Health, University College London, London, UK., Leboreiro-Babe C; Great Ormond Street Institute of Child Health, University College London, London, UK., Vitali A; Great Ormond Street Institute of Child Health, University College London, London, UK., Privitera L; Great Ormond Street Institute of Child Health, University College London, London, UK., O'Sullivan K; Great Ormond Street Institute of Child Health, University College London, London, UK., Greppi A; Great Ormond Street Institute of Child Health, University College London, London, UK., Buschhaus M; Lumicks, Amsterdam, The Netherlands., Román MB; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., de Blank S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., van den Ham F; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van 't Veld BR; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Ferry G; Great Ormond Street Institute of Child Health, University College London, London, UK., Fisher J; Great Ormond Street Institute of Child Health, University College London, London, UK., Shome D; Lumicks, Amsterdam, The Netherlands., Nadafi R; Lumicks, Amsterdam, The Netherlands., Ansari IH; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Reijmers R; Lumicks, Amsterdam, The Netherlands., Giuliani S; Great Ormond Street Institute of Child Health, University College London, London, UK., Sondel P; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Donovan LK; Great Ormond Street Institute of Child Health, University College London, London, UK., Chesler L; Cancer Institute, University College London, London, UK., Jan Molenaar; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Drost J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Rios AC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Chester K; The Institute of Cancer Research, London, UK., Wienke J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. j.wienke-4@prinsesmaximacentrum.nl., Anderson J; Great Ormond Street Institute of Child Health, University College London, London, UK. j.anderson@ucl.ac.uk.
Source: Nature communications [Nat Commun] 2025 Aug 05; Vol. 16 (1), pp. 7196. Date of Electronic Publication: 2025 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40764385
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Barisa+M%22">Barisa M</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK. m.barisa@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Muller+HP%22">Muller HP</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zappa+E%22">Zappa E</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Shah+R%22">Shah R</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Buhl+JL%22">Buhl JL</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Draper+B%22">Draper B</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Himsworth+C%22">Himsworth C</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bowers+C%22">Bowers C</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Munnings-Tomes+S%22">Munnings-Tomes S</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nicolaidou+M%22">Nicolaidou M</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Morlando+S%22">Morlando S</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Birley+K%22">Birley K</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Leboreiro-Babe+C%22">Leboreiro-Babe C</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Vitali+A%22">Vitali A</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Privitera+L%22">Privitera L</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+K%22">O'Sullivan K</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Greppi+A%22">Greppi A</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Buschhaus+M%22">Buschhaus M</searchLink>; Lumicks, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Román+MB%22">Román MB</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Blank+S%22">de Blank S</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Ham+F%22">van den Ham F</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+'t+Veld+BR%22">van 't Veld BR</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ferry+G%22">Ferry G</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Fisher+J%22">Fisher J</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Shome+D%22">Shome D</searchLink>; Lumicks, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nadafi+R%22">Nadafi R</searchLink>; Lumicks, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ansari+IH%22">Ansari IH</searchLink>; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Reijmers+R%22">Reijmers R</searchLink>; Lumicks, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Giuliani+S%22">Giuliani S</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sondel+P%22">Sondel P</searchLink>; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Donovan+LK%22">Donovan LK</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chesler+L%22">Chesler L</searchLink>; Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Jan+Molenaar%22">Jan Molenaar</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Drost+J%22">Drost J</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rios+AC%22">Rios AC</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chester+K%22">Chester K</searchLink>; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Wienke+J%22">Wienke J</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. j.wienke-4@prinsesmaximacentrum.nl.<br /><searchLink fieldCode="AU" term="%22Anderson+J%22">Anderson J</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK. j.anderson@ucl.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 05; Vol. 16 (1), pp. 7196. <i>Date of Electronic Publication: </i>2025 Aug 05.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40764385
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-025-61427-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 7196
    Titles:
      – TitleFull: Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Barisa M
      – PersonEntity:
          Name:
            NameFull: Muller HP
      – PersonEntity:
          Name:
            NameFull: Zappa E
      – PersonEntity:
          Name:
            NameFull: Shah R
      – PersonEntity:
          Name:
            NameFull: Buhl JL
      – PersonEntity:
          Name:
            NameFull: Draper B
      – PersonEntity:
          Name:
            NameFull: Himsworth C
      – PersonEntity:
          Name:
            NameFull: Bowers C
      – PersonEntity:
          Name:
            NameFull: Munnings-Tomes S
      – PersonEntity:
          Name:
            NameFull: Nicolaidou M
      – PersonEntity:
          Name:
            NameFull: Morlando S
      – PersonEntity:
          Name:
            NameFull: Birley K
      – PersonEntity:
          Name:
            NameFull: Leboreiro-Babe C
      – PersonEntity:
          Name:
            NameFull: Vitali A
      – PersonEntity:
          Name:
            NameFull: Privitera L
      – PersonEntity:
          Name:
            NameFull: O'Sullivan K
      – PersonEntity:
          Name:
            NameFull: Greppi A
      – PersonEntity:
          Name:
            NameFull: Buschhaus M
      – PersonEntity:
          Name:
            NameFull: Román MB
      – PersonEntity:
          Name:
            NameFull: de Blank S
      – PersonEntity:
          Name:
            NameFull: van den Ham F
      – PersonEntity:
          Name:
            NameFull: van 't Veld BR
      – PersonEntity:
          Name:
            NameFull: Ferry G
      – PersonEntity:
          Name:
            NameFull: Fisher J
      – PersonEntity:
          Name:
            NameFull: Shome D
      – PersonEntity:
          Name:
            NameFull: Nadafi R
      – PersonEntity:
          Name:
            NameFull: Ansari IH
      – PersonEntity:
          Name:
            NameFull: Reijmers R
      – PersonEntity:
          Name:
            NameFull: Giuliani S
      – PersonEntity:
          Name:
            NameFull: Sondel P
      – PersonEntity:
          Name:
            NameFull: Donovan LK
      – PersonEntity:
          Name:
            NameFull: Chesler L
      – PersonEntity:
          Name:
            NameFull: Jan Molenaar
      – PersonEntity:
          Name:
            NameFull: Drost J
      – PersonEntity:
          Name:
            NameFull: Rios AC
      – PersonEntity:
          Name:
            NameFull: Chester K
      – PersonEntity:
          Name:
            NameFull: Wienke J
      – PersonEntity:
          Name:
            NameFull: Anderson J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 08
              Text: 2025 Aug 05
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1