Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation.

Saved in:
Bibliographic Details
Title: Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation.
Authors: Akdeniz BC; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosicences, University of Oslo, Oslo, Norway., Bahrami S; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Hagen E; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fuhrer J; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fominykh V; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Shadrin A; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Filiz TT; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Athanasiu L; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Grenier-Boley B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Bellenguez C; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria., Scherbaum N; Department of Psychiatry and Psychotherapy, LVR-University Hospital Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany.; Institute of Clinical Epidemiology and Biometrics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Germany., Molina-Porcel L; Neurological Tissue Bank - Biobanc- Hospital Clinic -IDIBAPS, Barcelona, Spain.; Alzheimer's disease and other cognitive disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Grimmer T; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, TUM University Hospital, Technical University of Munich, School of Medicine, Munich, Germany., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Scarmeas N; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., García-Alberca JM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., Franco-Macías E; Unidad de Demencias, Servicio de Neurología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Mir P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Seville, Spain., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Departamento de Bioquímica Médica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.; CIBERINFEC, Network Center for Biomedical Research in Infectious Diseases, National Institute of Health Carlos III, Madrid, Spain., Rodriguez-Rodriguez E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Carracedo Á; Grupo de Medicina Xenómica, Centro en Red de Investigación en Enfermedades Raras (CIBERER-ISCIII), CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación de Medicina Xenómica, Servicio Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain., de Munain AL; Department of Neurology, Hospital Universitario Donostia-Instituto Biodonostia-OSAKIDETZA-EHU-CIBERNED, San Sebastian, Spain.; Department of Neurosciences, Faculty of Medicine and Nursery, University of the Basque Country, San Sebastián, Spain., Amer-Ferrer G; Department of Neurology, Hospital Universitario Son Espases, Palma, Spain., Calero M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Medina M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Mendioroz M; Navarrabiomed, Pamplona, Spain.; Department of Neurology, Hospital Universitario de Navarra, Pamplona, Spain., Dols-Icardo O; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Moreno F; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia-Instituto Biodonostia-OSAKIDETZA-EHU-CIBERNED, San Sebastian, Spain.; Biogipuzkoa Health Research Institute, Neurosciences Area, Group of Neurodegenerative Diseases, 20014 San Sebastián, Spain., Pérez-Tur J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain., Bullido MJ; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain., Soininen H; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Traykov L; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Hort J; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic., Vyhnalek M; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic., Sandau N; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Thomassen JQ; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Luo J; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Tesi N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of technology, Delft, The Netherlands., van Swieten J; Department of Neurology, ErasmusMC, Rotterdam, The Netherlands., Giedraitis V; Dept. of Public Health and Caring Sciences / Geriatrics, Uppsala University, Uppsala, Sweden., Williams J; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Nicolas G; Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and CNR-MAJ, F-76000 Rouen, France., Debette S; University of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France.; CHU de Bordeaux, Pole santé publique, Bordeaux, France.; Institut du Cerveau (ICM), Paris Brain Institute, INSERM U1127, UMR CNRS 7225 Paris, Sorbonne Université, Assistance Publique des Hôpitaux de Paris, Paris, France., Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Popp J; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Adult Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland., Bossù P; Experimental Neuro-psychobiology Laboratory, IRCCS Fondazione Santa Lucia, Rome, Italy., Galimberti D; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Rossi G; Unit of Neurology 8, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.; Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Tremolizzo L; Neurology Unit, IRCCS 'San Gerardo dei Tintori', Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Borroni B; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Seripa D; Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Rainero I; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy., Daniele A; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy., Piras F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Kehoe PG; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health San Antonio, TX 78229-3900, USA., Fernandez V; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Sánchez-Juan P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Madrid, Spain., Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Ingelsson M; Dept. of Public Health and Caring Sciences / Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Sims R; Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Disease (CECAD), University of Cologne, Cologne, Germany., Broce IJ; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Haavik J; Department of Biomedicine, University of Bergen, Bergen, Norway.; Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway., Selbæk G; Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway., Knapskog AB; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Saltvedt I; Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway and Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Bergh S; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.; Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway., Aakhus E; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway., Kirsebom BE; Department of Neurology, University Hospital of North Norway, Tromsø; Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Watne LO; Oslo Delirium Research Group, Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway., Rongve A; Department of Research and Innovation, Helse Fonna, Haugesund, Norway.; University of Bergen, Department of Clinical Medicine (K1), Bergen, Norway., Årsland D; Centre for Age - Related Medicine, Stavanger University Hospital, Stavanger, Norway.; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Djurovic S; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Stordal E; Department of Psychiatry, Namsos Hospital, Namsos, Norway., Toft M; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Scheffler K; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Fladby T; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Dale A; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.; Department of Radiology, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Cognitive Science, University of California San Diego, La Jolla, CA, USA., Frei O; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosicences, University of Oslo, Oslo, Norway., Andreassen O; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jul 28. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.07.28.25332293