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Vagal blockade of the brain-liver axis deters cancer-associated cachexia.

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Title: Vagal blockade of the brain-liver axis deters cancer-associated cachexia.
Authors: Garrett A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Darzi N; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel., Deshmukh A; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA., Rosenfeld N; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel., Goldman O; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel., Adler L; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel., Bab-Dinitz E; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel., Singer O; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel., Hassani Najafabadi A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Wong CW; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bose S; Department of Internal Medicine, University of Chicago, Chicago, IL 60637, USA., Randon PM; Medical Scientist Training Program, Vanderbilt University Medical School, Nashville, TN 37235, USA., Bustamante F; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Larios R; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Brandis A; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel., Mehlman T; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel., Smaglo B; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang P; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Oliva J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Haymaker C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nagawekar L; Clinical Engineering and Applied Research, Abbot Laboratories, Sylmar, CA 91342, USA., Wu SR; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Huang Y; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Shen A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Vora A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Padilla JF; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Pfeffer A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Sutherland G; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA., Starr M; Department of Medicine, Duke University, Durham, NC 27708, USA., Zimmers T; Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Zhu Y; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Morizio J; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA., Erez A; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: ayelet.erez@weizmann.ac.il., Shen X; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: xshen3@mdanderson.org.
Source: Cell [Cell] 2025 Oct 16; Vol. 188 (21), pp. 6044-6063.e24. Date of Electronic Publication: 2025 Aug 07.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Vagal blockade of the brain-liver axis deters cancer-associated cachexia.
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  Data: <searchLink fieldCode="AU" term="%22Garrett+A%22">Garrett A</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Darzi+N%22">Darzi N</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Deshmukh+A%22">Deshmukh A</searchLink>; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.<br /><searchLink fieldCode="AU" term="%22Rosenfeld+N%22">Rosenfeld N</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Goldman+O%22">Goldman O</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Adler+L%22">Adler L</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Bab-Dinitz+E%22">Bab-Dinitz E</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Singer+O%22">Singer O</searchLink>; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Hassani+Najafabadi+A%22">Hassani Najafabadi A</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Wong+CW%22">Wong CW</searchLink>; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bose+S%22">Bose S</searchLink>; Department of Internal Medicine, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Randon+PM%22">Randon PM</searchLink>; Medical Scientist Training Program, Vanderbilt University Medical School, Nashville, TN 37235, USA.<br /><searchLink fieldCode="AU" term="%22Bustamante+F%22">Bustamante F</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Larios+R%22">Larios R</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Brandis+A%22">Brandis A</searchLink>; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Mehlman+T%22">Mehlman T</searchLink>; Department of Life Science Core Facilities, Weizmann Institute of Science, 7610001 Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Smaglo+B%22">Smaglo B</searchLink>; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chang+P%22">Chang P</searchLink>; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Oliva+J%22">Oliva J</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Haymaker+C%22">Haymaker C</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nagawekar+L%22">Nagawekar L</searchLink>; Clinical Engineering and Applied Research, Abbot Laboratories, Sylmar, CA 91342, USA.<br /><searchLink fieldCode="AU" term="%22Wu+SR%22">Wu SR</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.<br /><searchLink fieldCode="AU" term="%22Shen+A%22">Shen A</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Vora+A%22">Vora A</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Padilla+JF%22">Padilla JF</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Pfeffer+A%22">Pfeffer A</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Sutherland+G%22">Sutherland G</searchLink>; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Starr+M%22">Starr M</searchLink>; Department of Medicine, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Zimmers+T%22">Zimmers T</searchLink>; Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.<br /><searchLink fieldCode="AU" term="%22Morizio+J%22">Morizio J</searchLink>; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Erez+A%22">Erez A</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: ayelet.erez@weizmann.ac.il.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: xshen3@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Oct 16; Vol. 188 (21), pp. 6044-6063.e24. <i>Date of Electronic Publication: </i>2025 Aug 07.
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