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Physical and chemical niche of human growth plate for polarized bone development.

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Title: Physical and chemical niche of human growth plate for polarized bone development.
Authors: Xie C; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Li W; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Yao X; Center of Regenerative and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China., Wu B; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Fang J; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China., Mao R; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China., Yan Y; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Meng H; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China., Wu Y; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China., Zhang X; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Li R; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Zhang J; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China., Duan W; Department of Orthopedics, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China., Dai X; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China., Wang X; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China. xiaozhaowang@zju.edu.cn.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China. xiaozhaowang@zju.edu.cn.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China. xiaozhaowang@zju.edu.cn.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China. xiaozhaowang@zju.edu.cn., Ouyang H; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China. hwoy@zju.edu.cn.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China. hwoy@zju.edu.cn.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China. hwoy@zju.edu.cn.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China. hwoy@zju.edu.cn.
Source: Nature communications [Nat Commun] 2025 Aug 08; Vol. 16 (1), pp. 7328. Date of Electronic Publication: 2025 Aug 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-62711-z