The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study.
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| Title: | The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study. |
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| Authors: | Hyle EP; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: ehyle@mgh.harvard.edu., Bekker LG; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., McCluskey SM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa., Chen W; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Sax PE; Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Moosa MY; Department of Infectious Diseases, University of KwaZulu-Natal, Durban, South Africa., Machoko M; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Bangs A; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Steegen K; National Priority Programme, National Health Laboratory Service, Johannesburg, South Africa; Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa., Siedner MJ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, KwaZulu-Natal, South Africa., van de Vijver DAMC; Department of Viroscience, Erasmus University Rotterdam, Rotterdam, Netherlands., Resch SC; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA., Neilan AM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Academic Pediatrics, Massachusetts General Hospital, Boston, MA, USA., Phillips A; Epidemiology and Biostatistics, University College London, London, UK., Walensky RP; Harvard Kennedy School, Cambridge, MA, USA; American Academy of Berlin, Berlin, Germany., Lessells RJ; KwaZulu-Natal Research and Innovation Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Weinstein MC; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA., Dugdale CM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Wood R; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa., Freedberg KA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA. |
| Source: | The lancet. HIV [Lancet HIV] 2025 Sep; Vol. 12 (9), pp. e627-e637. Date of Electronic Publication: 2025 Aug 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40782815 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hyle+EP%22">Hyle EP</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: ehyle@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Bekker+LG%22">Bekker LG</searchLink>; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22McCluskey+SM%22">McCluskey SM</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sax+PE%22">Sax PE</searchLink>; Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Moosa+MY%22">Moosa MY</searchLink>; Department of Infectious Diseases, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Machoko+M%22">Machoko M</searchLink>; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bangs+A%22">Bangs A</searchLink>; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Steegen+K%22">Steegen K</searchLink>; National Priority Programme, National Health Laboratory Service, Johannesburg, South Africa; Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Siedner+MJ%22">Siedner MJ</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22van+de+Vijver+DAMC%22">van de Vijver DAMC</searchLink>; Department of Viroscience, Erasmus University Rotterdam, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Resch+SC%22">Resch SC</searchLink>; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Neilan+AM%22">Neilan AM</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Academic Pediatrics, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+A%22">Phillips A</searchLink>; Epidemiology and Biostatistics, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Walensky+RP%22">Walensky RP</searchLink>; Harvard Kennedy School, Cambridge, MA, USA; American Academy of Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lessells+RJ%22">Lessells RJ</searchLink>; KwaZulu-Natal Research and Innovation Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Weinstein+MC%22">Weinstein MC</searchLink>; Center for Health Decision Science, Harvard T H Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dugdale+CM%22">Dugdale CM</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+R%22">Wood R</searchLink>; Desmond Tutu HIV Center, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Freedberg+KA%22">Freedberg KA</searchLink>; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101645355%22">The lancet. HIV</searchLink> [Lancet HIV] 2025 Sep; Vol. 12 (9), pp. e627-e637. <i>Date of Electronic Publication: </i>2025 Aug 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101645355 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3018 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523018%22">23523018 </searchLink><i>NLM ISO Abbreviation: </i>Lancet HIV <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40782815 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2352-3018(25)00164-X Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e627 Titles: – TitleFull: The clinical and economic impact of genotypic resistance testing for people diagnosed with persistent virological non-suppression on tenofovir-lamivudine-dolutegravir in South Africa: a modelling study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hyle EP – PersonEntity: Name: NameFull: Bekker LG – PersonEntity: Name: NameFull: McCluskey SM – PersonEntity: Name: NameFull: Chen W – PersonEntity: Name: NameFull: Sax PE – PersonEntity: Name: NameFull: Moosa MY – PersonEntity: Name: NameFull: Machoko M – PersonEntity: Name: NameFull: Bangs A – PersonEntity: Name: NameFull: Steegen K – PersonEntity: Name: NameFull: Siedner MJ – PersonEntity: Name: NameFull: van de Vijver DAMC – PersonEntity: Name: NameFull: Resch SC – PersonEntity: Name: NameFull: Neilan AM – PersonEntity: Name: NameFull: Phillips A – PersonEntity: Name: NameFull: Walensky RP – PersonEntity: Name: NameFull: Lessells RJ – PersonEntity: Name: NameFull: Weinstein MC – PersonEntity: Name: NameFull: Dugdale CM – PersonEntity: Name: NameFull: Wood R – PersonEntity: Name: NameFull: Freedberg KA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2025 Sep Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2352-3018 Numbering: – Type: volume Value: 12 – Type: issue Value: 9 Titles: – TitleFull: The lancet. HIV Type: main |
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