Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

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Title: Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.
Authors: Gollihue JL; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA., Aung KZ; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA.; Department of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Rogers CB; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA., Galopin LB; Department of Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA., Wright NA; Department of Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA., Sompol P; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA.; Department of Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA., Weekman EM; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA., Katsumata Y; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA.; Department of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Morganti JM; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA. josh.morganti@uky.edu.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA. josh.morganti@uky.edu., Norris CM; Sanders-Brown Center On Aging, University of Kentucky College of Medicine, Lexington, KY, USA. cnorr2@uky.edu.; Department of Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA. cnorr2@uky.edu.
Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Aug 09; Vol. 22 (1), pp. 202. Date of Electronic Publication: 2025 Aug 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1742-2094
DOI:10.1186/s12974-025-03523-2