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Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.

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Title: Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Authors: Omo-Lamai S; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Wang Y; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Patel MN; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Milosavljevic A; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Zuschlag D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Poddar S; Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wu J; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang L; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Dong F; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Espy C; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Majumder A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Essien EO; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shen M; Emergency Medical Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Channer B; Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA., Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tobin M; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Maheshwari R; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA., Jeong S; Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX, USA., Patel S; Department of Chemical Engineering, School of Engineering and Applied Sciences, University of Virginia, Charlottesville, VA, USA., Shah A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Murali S; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chase LS; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Zamora ME; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Arral ML; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA., Marcos-Contreras OA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Myerson JW; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hunter CA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Discher D; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Gaskill PJ; Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA., Tsourkas A; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brodsky I; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shin S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Whitehead KA; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA., Parhiz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Katzen J; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miner JJ; Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Trauner D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Brenner JS; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.
Source: Nature nanotechnology [Nat Nanotechnol] 2025 Sep; Vol. 20 (9), pp. 1285-1297. Date of Electronic Publication: 2025 Aug 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE
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Jacob.Brenner@pennmedicine.upenn.edu.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.
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