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Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies.

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Title: Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies.
Authors: Xu W; Merck & Co., Inc., Rahway, New Jersey, USA., Antonello J; Merck & Co., Inc., Rahway, New Jersey, USA., Nguyen J; Merck & Co., Inc., Rahway, New Jersey, USA., Ma C; Merck & Co., Inc., Rahway, New Jersey, USA., Cheng YW; Merck & Co., Inc., Rahway, New Jersey, USA., Marullo K; Merck & Co., Inc., Rahway, New Jersey, USA., Nolan K; Merck & Co., Inc., Rahway, New Jersey, USA., Buchwald UK; Merck & Co., Inc., Rahway, New Jersey, USA., Platt HL; Merck & Co., Inc., Rahway, New Jersey, USA., Bonhomme M; PPD Clinical Research Group, Thermo Fisher Scientific, Richmond, Virginia, USA., LaFon DC; Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Burton RL; SunFire Biotechnologies LLC, Birmingham, Alabama, USA., Nahm MH; Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Helmy R; Merck & Co., Inc., Rahway, New Jersey, USA.
Source: The Journal of infectious diseases [J Infect Dis] 2026 Jan 17; Vol. 233 (1), pp. 101-111.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies.
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  Data: <searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Antonello+J%22">Antonello J</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+YW%22">Cheng YW</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Marullo+K%22">Marullo K</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Nolan+K%22">Nolan K</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Buchwald+UK%22">Buchwald UK</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Platt+HL%22">Platt HL</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Bonhomme+M%22">Bonhomme M</searchLink>; PPD Clinical Research Group, Thermo Fisher Scientific, Richmond, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22LaFon+DC%22">LaFon DC</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Burton+RL%22">Burton RL</searchLink>; SunFire Biotechnologies LLC, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Nahm+MH%22">Nahm MH</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Helmy+R%22">Helmy R</searchLink>; Merck & Co., Inc., Rahway, New Jersey, USA.
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  Data: <searchLink fieldCode="JN" term="%220413675%22">The Journal of infectious diseases</searchLink> [J Infect Dis] 2026 Jan 17; Vol. 233 (1), pp. 101-111.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413675 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1537-6613 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221899%22">00221899 </searchLink><i>NLM ISO Abbreviation: </i>J Infect Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1093/infdis/jiaf427
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        Text: English
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              Text: 2026 Jan 17
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