PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity.
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| Title: | PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity. |
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| Authors: | Eggenschwiler R; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Hoffmann T; Molecular Systems Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany., Dmytrenko O; Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, 97080 Würzburg, Germany., Opitz M; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Ackel-Zakour M; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Wang P; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., McCallan SA; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Fráguas-Eggenschwiler M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany., Niemann H; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany., Patronov A; Discovery Sciences, R&D, AstraZeneca Gothenburg, 43183 Mölndal, Sweden., Beisel CL; Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, 97080 Würzburg, Germany.; Medical Faculty, University of Würzburg, 97080 Würzburg, Germany., Cantz T; Research Group Translational Hepatology and Stem Cell Biology, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2025 Aug 11; Vol. 53 (15). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkaf782 |
