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Safety and Efficacy of the NMDA-2b-Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder.

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Title: Safety and Efficacy of the NMDA-2b-Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder.
Authors: McIntyre RS; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Sanacora G; Yale University, New Haven, Connecticut, USA., Walling DP; CenExel CNS, Garden Grove, California, USA., Cohen EA; CenExel Hassman Research Institute, Marlton, New Jersey, USA., Malhotra S; Neuro-Behavioral Clinical Research, Canton, Ohio, USA., Rosenbrock H; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Schmitz M; mainanalytics GmbH, Sulzbach/Taunus, Germany., Scholz A; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany., Süssmuth SD; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., De Crescenzo F; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Nov; Vol. 118 (5), pp. 1202-1212. Date of Electronic Publication: 2025 Aug 14.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and Efficacy of the NMDA-2b-Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder.
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  Data: <searchLink fieldCode="AU" term="%22McIntyre+RS%22">McIntyre RS</searchLink>; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sanacora+G%22">Sanacora G</searchLink>; Yale University, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Walling+DP%22">Walling DP</searchLink>; CenExel CNS, Garden Grove, California, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+EA%22">Cohen EA</searchLink>; CenExel Hassman Research Institute, Marlton, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+S%22">Malhotra S</searchLink>; Neuro-Behavioral Clinical Research, Canton, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Rosenbrock+H%22">Rosenbrock H</searchLink>; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz+M%22">Schmitz M</searchLink>; mainanalytics GmbH, Sulzbach/Taunus, Germany.<br /><searchLink fieldCode="AU" term="%22Scholz+A%22">Scholz A</searchLink>; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22Süssmuth+SD%22">Süssmuth SD</searchLink>; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22De+Crescenzo+F%22">De Crescenzo F</searchLink>; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
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              Text: 2025 Nov
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