Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization.

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Title: Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization.
Authors: Chhabra A; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Hoffmann C; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Aguilar Pérez G; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Korobeinikov AA; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany., Rentsch J; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany., Hümpfer N; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany., Kokwaro L; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Institute of Biochemistry and Einstein Center for Neurosciences, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117, Berlin, Germany., Gnidovec L; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany., Petrović A; Institute for Neuropathology, University Medical Center Göttingen, 37073, Göttingen, Germany., Wallace JN; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Tromm JV; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA.; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Román-Vendrell C; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Johnson EC; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Ranković B; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Perego E; Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany., Volpi T; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, 06520, USA., Fernández-Busnadiego R; Institute for Neuropathology, University Medical Center Göttingen, 37073, Göttingen, Germany., Köster S; Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany., Rizzoli SO; Institute for Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073, Göttingen, Germany., Ewers H; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany., Morgan JR; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, 02543, Woods Hole, MA, USA., Milovanović D; Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany. dragomir.milovanovic@dzne.de.; Whitman Center, Marine Biological Laboratory, 02543, Woods Hole, MA, USA. dragomir.milovanovic@dzne.de.; Institute of Biochemistry and Einstein Center for Neurosciences, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117, Berlin, Germany. dragomir.milovanovic@dzne.de.
Source: The EMBO journal [EMBO J] 2025 Sep; Vol. 44 (18), pp. 5112-5148. Date of Electronic Publication: 2025 Aug 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00516-y