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Activated Protein C Suppresses Cardiomyocyte Senescence in Diabetic Cardiomyopathy via PAR1/PAR3-P85-CaMKIIδ Axis.

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Title: Activated Protein C Suppresses Cardiomyocyte Senescence in Diabetic Cardiomyopathy via PAR1/PAR3-P85-CaMKIIδ Axis.
Authors: Zhang Y; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Dai L; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Wang M; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Zhong X; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Liu X; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Zhang K; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Luo L; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Wang L; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Dong W; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Vaczy A; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary., Li L; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary., Atlasz T; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary., Madhusudhan T; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany., Xu C; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China., Wang H; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.; Department of Cardiology, Tongji Xianning Hospital, Xianning, Hubei, China., Zeng H; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.
Source: Diabetes [Diabetes] 2025 Oct 01; Vol. 74 (10), pp. 1802-1813.
Publication Type: Journal Article
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Activated Protein C Suppresses Cardiomyocyte Senescence in Diabetic Cardiomyopathy via PAR1/PAR3-P85-CaMKIIδ Axis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Dai+L%22">Dai L</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Zhong+X%22">Zhong X</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Luo+L%22">Luo L</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Dong+W%22">Dong W</searchLink>; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Vaczy+A%22">Vaczy A</searchLink>; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary.<br /><searchLink fieldCode="AU" term="%22Atlasz+T%22">Atlasz T</searchLink>; Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; ELKH-PTE PACAP Research Team, Department of Anatomy, Medical School, University of Pécs, Pécs, Hungary.<br /><searchLink fieldCode="AU" term="%22Madhusudhan+T%22">Madhusudhan T</searchLink>; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.; Department of Cardiology, Tongji Xianning Hospital, Xianning, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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