Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron-Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap.
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| Title: | Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron-Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap. |
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| Authors: | Alston AB; CSL Vifor, Flughofstrasse 61, 8152, Glattbrugg, Switzerland. amy.barton@viforpharma.com., Lin Z; Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32610, USA., Gustafson HH; Department of Pediatrics, Ben Towne Center for Childhood Cancer and Blood Disorders Research, University of Washington, Seattle, WA, 98101, USA., Flühmann B; CSL Vifor, Flughofstrasse 61, 8152, Glattbrugg, Switzerland., Digigow R; CSL Vifor, Flughofstrasse 61, 8152, Glattbrugg, Switzerland., Ayala-Nunez V; Nanomaterials in Health Laboratory, Empa - Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland., Schmidt S; Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, 32827, USA. |
| Source: | Clinical pharmacokinetics [Clin Pharmacokinet] 2025 Oct; Vol. 64 (10), pp. 1477-1494. Date of Electronic Publication: 2025 Aug 15. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1179-1926 |
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| DOI: | 10.1007/s40262-025-01561-w |
